POFUT1 POINT-MUTATIONS THAT DISRUPT O-FUCOSYLTRANSFERASE ACTIVITY DESTABILIZE THE PROTEIN AND ABOLISH NOTCH1 SIGNALING DURING MOUSE SOMITOGENESIS.

Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.

The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM).This periodical process is controlled by the Word Art cyclic and synchronized activation of Notch signaling in the PSM.Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Notch1

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Comparative transcriptomic analysis delineates adaptation strategies of Rana kukunoris toward cold stress on the Qinghai-Tibet Plateau

Abstract Background Cold hardiness is fundamental for amphibians to survive during the extremely cold winter on the Qinghai-Tibet plateau.Exploring the gene regulation mechanism of freezing-tolerant Rana kukunoris could help us to understand how the frogs survive in winter.Results Transcriptome of liver and muscle of R.kukunoris collected in hibern

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Public crack copyright smoking and willingness to use a supervised inhalation facility: implications for street disorder

Abstract Background The health risks of crack copyright smoking in public settings have not been well described.We sought to identify factors associated with public crack smoking, and assess the potential for a supervised inhalation facility to reduce engagement in this behavior, in a setting planning to evaluate a medically supervised crack copyri

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Application of Precision Agriculture Technologies for Sustainable Crop Production and Environmental Sustainability: A Systematic Review

Precision agriculture technologies (PATs) transform crop production by enabling more sustainable and efficient agricultural practices.These technologies utilize data-driven approaches to optimize the management of crops, soil, and resources, thus enhancing both productivity and environmental sustainability.This article reviewed the application of P

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